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KMID : 0604520080340020149
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Journal of the Society of Cosmetic Scientists of Korea
2008 Volume.34 No. 2 p.149 ~ p.156
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The Inhibitory Effects of Acanthopanax sessiliflorum Seeman on Melanogenesis
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Lim Kyung-Ran
Kim Mi-Jin
Jung Taek-Kyu
Yoon Kyung-Sup
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Abstract
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To develop a new natural whitening agent for cosmetics, we investigated effects of Acanthopanax sessiliflorum Seeman on melanogenesis. We prepared phenolic acid-rich extract including two phenolic acids, chlorogenic acid and caffeic acid, as predominant constituents from Acanthopanax sessiliflorum Seeman. Phenolic acid-rich extract showed ROS scavenging activities in 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical and xanthine/xanthine oxidase system with the values of and , respectively. Phenolic acid-rich fraction reduced melanin contents of B16 melanoma cells dose-dependantly and the decrease was at a concentration of . And the phenolic acid-rich fraction reduced intracellular tyrosinase activity about at a concentration of . Phenolic acid-rich extract inhibited tyrosinase and TRP-2 expression at protein level. These results suggest that phenolic acid-rich fraction reduced melanin formation by the inhibitions of tyrosinase activity and expression in B16 melanoma cells. Therefore, we suggest that phenolic acid-rich extract could be used as a whitening ingredient in cosmetics.
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KEYWORD
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whitening, Acanthopanax sessiliflorum Seeman, melanogenesis, tyrosinase, TRP-2
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